Producers Resource Center

Aging Heart Can Be Prevented

Old age is a major risk factor for heart failure, a condition when the heart is unable to pump enough blood around to supply the oxygen the body needs.  Some 5.7 million Americans have heart failure, and nearly 10 out of every 1,000 people over age 65 suffer heart failure every year according to the American Association for Critical Illness Insurance

Japanese researchers at Kyoto University Graduate School of Medicine in Kyoto described how they managed to suppress a variety of the P13K gene in a group of elderly mice.  The gene regulates the lifespan of cells and plays a role in the aging of tissues. 

Prior studies found that the suppression of this gene extended the lifespan roundworm and kept the hearts of old fruit flies healthy.  The Japanese researchers reported that compared with another group of mice in which the gene was left intact, mice with the suppressed gene had improved cardiac function and fewer biological markers of aging. 

The medical researchers noted that mice are considered a good surrogate for studies of human diseases and conditions.  Their body plan, physiology and genome share many features with humans they note. The findings were published in the journal Circulation.

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