Producers Resource Center

Hops Compound May Prevent Prostate Cancer

Medical researchers at the German Cancer Research Center, in Heidelberg, Germany have presented findings at the American Association for Cancer Research Frontiers in Cancer Prevention Research Conference. 

The natural compound, xanthohumol, is derived from hops and belongs to the group of flavonoids that are found in many plants, fruit, vegetables and spices. Studies to date have shown that xanthohumol blocks the action of estrogen by binding to its receptor, which may lead to prevention of breast cancer. 

The researchers examined whether xanthohumol might not only block the effects of the male hormone androgen.  Researchers stimulated hormone-dependent prostate cancer cells with testosterone, which led to a massive secretion of prostate specific antigen (PSA). PSA is used for screening and early detection of prostate cancer in men. Cells were then treated with testosterone and xanthohumol and the effects were examined.

They found that xanthohumol inhibited its potential to stimulate the secretion of PSA and other hormone-dependent effects.  Molecular modeling results showed that xanthohumol directly binds to the androgen receptor structure. 

The researchers suggest that this compound may have beneficial effects in animals.  When they measured the anti-androgenic potential of xanthohumol in rats, they found that although xanthohumol was not able to prevent an increase in prostate weight after testosterone treatment, it could reduce testosterone-increased seminal vesicle weight. 

Data posted by the American Association for Critical Illness Insurance that tracks data and research on the three primary critical illnesses, cancer, heart attack and stroke.

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