Producers Resource Center

Stem Cell Research Offers Colon Cancer Vaccine Hope

October 10, 2009.  Human stem cells may provide a means of creating a vaccine against colon cancer and other types of cancers.

Some 1.4 million Americans are diagnosed with cancer annually according to the American Association for Critical Illness Insurance, the national trade orgganization.  “Some 10 percent of cases in both men and women are colon cancer,” notes Jesse Slome, executive director.

American and Chinese scientists reporting noted that cancer and stem cells share many molecular and biological features.   Dr. Zihai Li, of the University of Connecticut Stem Cell Institute, said in a news release that by immunizing the host with stem cells, the researchers were are able to ‘fool’ the immune system to believe that cancer cells are present and thus to initiate a tumor-combating immune program.  The research by Li and colleagues is the first to make the connection between human stem cells and colon cancer vaccination.

 

The study authors noted that, it has long been believed that immunizing people with embryonic materials may trigger an anti-tumor response by the immune system, but this theory has never advanced beyond animal research. The finding that human stem cells may help immunize against colon cancer is new and unexpected they added.  The study was published online Oct. 7 in the journal Stem Cells.

 

The researchers vaccinated mice with human embryonic stem cells and found that the mice developed a consistent immune response against colon cancer cells. The vaccinated mice showed a dramatic decline in tumor growth, compared with non-vaccinated mice.

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