Posts Tagged ‘liver cancer’

Protein Could Yield Treatments For Liver Cancer

Tuesday, December 22nd, 2009

Research from United States and Japanese scientists explain that learning more about how TAK1 works could improve understanding about the development of liver disease and cancer, and lead to new therapies.

The researchers noted these findings in their report, released online in advance of publication in an upcoming print issue of the Proceedings of the National Academy of Sciences.

TAK1 appears to be a master regulator of liver function according to the dean of the University of California San Diego School of Medicine statement issued in a university news release. 

It was already known that TAK1 activates two proteins that play a role in immunity, inflammation, programmed cell death and cancer. But it wasn’t clear whether TAK1 promotes or prevents liver cancer.

To investigate this question, scientists created mice with liver cells that lacked TAK1 and found that the mice had a high rate of liver cell death. To compensate, the rodents’ livers produced too many cells, resulting in liver damage that led to liver cancer, the researchers found. 

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